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The Buratowski lab studies mechanisms of eukaryotic gene expression, focusing on RNA polymerase II transcription initiation, elongation, and termination, as well as the co-transcriptional processing of mRNA.  We use a wide array of approaches, including classic molecular genetics, genomics, protein biochemistry, mass spectrometry, and single molecule microscopy.  

Current projects include:

  • Coupling of mRNA processing to transcription via phosphorylation of the RNA polymerase II C-terminal domain (CTD)

  • The interplay between transcription and chromatin modifications, especially methylations of histone H3

  • The role of overlapping non-coding RNA transcription in modifying mRNA expression

  • The proteomics of transcription initiation and elongation (in collaboration with Jarrod Marto, DFCI/HMS)

  • Single molecule studies of RNA polymerase II transcription (in collaboration with Jeff Gelles, Brandeis University)

 


 

SOME LAB MOVIES:

Video: Steve talks about the lab's research on gene expression at the sgreen加速器官网:2021-5-29 · sgreen加速器 苹果下载 安卓 下载 sgreen加速器安卓版 版本号:1.1.1 时间:06-11 下载 sgreen加速器 安卓版 版本号:1.1.2 时间:06-09 下载 sgreen加速器 苹果版 版本号:1.1.1 时间:06-11 ...


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Video: A movie celebrating many years of Robin's cakes for lab birthdays, graduations, etc.!

 

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